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Suppressed on a stable regimen
The current label requires HIV-1 RNA below 50 copies/mL on a stable antiretroviral regimen.
Keep the HIV clinician in the loop
An ASOC administration visit does not replace the clinician who manages HIV treatment, laboratory monitoring, resistance history, interactions, or an oral bridging plan.
What the referring HIV clinician must confirm
The ASOC workflow starts only after the treating HIV clinician confirms that CABENUVA is clinically appropriate and provides a complete continuation plan.
No failure or relevant resistance
There must be no history of treatment failure and no known or suspected resistance to cabotegravir or rilpivirine.
Age and weight
The current indication includes adults and adolescents age 12 or older who weigh at least 35 kg.
Interaction and history review
The prescriber reviews current and prior antiretrovirals, resistance results, hepatitis or liver history, pregnancy, mental health, allergies, and interacting medicines.
How referral-based administration is coordinated
Do not stop the current oral regimen, ship medication, or change an injection date until the treating clinician and administration site confirm the plan.
1. Referring-clinician records
Send the current regimen, recent viral load, treatment and resistance history, medication list, allergies, selected schedule, target date, and responsible prescriber contact.
2. Benefits and medication pathway
The care teams identify whether the medication is handled through the pharmacy or medical benefit, complete any authorization steps, and confirm delivery and storage before scheduling administration.
3. Oral lead-in decision
The patient and healthcare provider may use an oral lead-in to assess tolerability or proceed directly to injections. The ASOC does not make this decision without the treating HIV clinician.
4. Two injections at one visit
A complete dose is one cabotegravir injection and one rilpivirine injection at separate gluteal sites. The label calls for brief observation, approximately 10 minutes, after administration.
5. Return records and next date
The administration record, reactions, next target date, and any follow-up concern go back to the treating HIV clinician so treatment remains continuous.
6. Plan missed doses before they happen
CABENUVA may be given up to seven days before or after the target date. A delay beyond that window can require oral bridging or re-initiation under the prescriber's direction.
Why scheduling and safety review cannot be separated
Long-acting medicine remains in the body after an injection, so missed doses, discontinuation, and interacting drugs require an active treatment plan.
Post-injection reactions
Serious reactions have occurred within minutes after rilpivirine injection. Trouble breathing, dizziness, flushing, sweating, oral numbness, blood-pressure changes, and chest or back pain require immediate on-site assessment.
Hypersensitivity
Severe rash, fever, mouth or eye involvement, facial swelling, or breathing difficulty can signal a serious reaction. The label directs immediate discontinuation and clinical evaluation when hypersensitivity is suspected.
Liver and mental-health review
Hepatotoxicity and depressive disorders have been reported. Report jaundice, dark urine, severe abdominal symptoms, worsening depression, or suicidal thoughts promptly.
Long-acting medication tail
Residual drug can remain for 12 months or longer. If CABENUVA stops, a fully suppressive alternative regimen must begin within the labeled time frame under the HIV clinician's direction.
Call the treatment team as soon as a dose may be late
Do not wait for the next routine visit if an injection may fall outside the seven-day window. Contact the treating HIV clinician and administration site immediately. Call 911 for trouble breathing, severe chest symptoms, fainting, facial swelling, or a severe blistering rash.
Medication, administration, laboratory, and prescriber costs can differ
Coverage can depend on the medical benefit, pharmacy benefit, prior authorization, specialty-pharmacy delivery, administration claim, and whether the ASOC is in network. Confirm each part before medication ships.
A benefits review is not a guarantee of payment. Ask the insurer, pharmacy, referring office, and administration site which organization owns each step and what may be billed separately.
What to bring
Complete records reduce delays, duplicate testing, and avoidable medication errors.
- Current antiretroviral regimen and the date of the last dose.
- Recent HIV-1 RNA result and relevant resistance or treatment-failure history.
- Selected monthly or every-two-month schedule and target treatment date.
- Complete medication, supplement, allergy, liver, pregnancy, and mental-health history.
- Referring HIV clinician contact, authorization status, medication source, and delivery plan.
Evaluation and coordination locations
Call first to confirm the correct visit, clinician, testing, medication, infection-control, and site-capability requirements. A location card is not a promise of medication stock or same-day administration.
Bronx
174th Street
932 E 174th St, Bronx, NY 10460
This location card supports referral and scheduling coordination only. Call before medication is shipped to confirm site capability, trained staff, storage, coverage, and the target appointment date. Serves West Farms, Crotona Park East, and nearby Bronx neighborhoods.
Queens
Astoria
37-15 23rd Ave, Astoria, NY 11105
This location card supports referral and scheduling coordination only. Call before medication is shipped to confirm site capability, trained staff, storage, coverage, and the target appointment date. Serves Astoria, Ditmars, East Elmhurst, and nearby Queens neighborhoods.
Bronx
Bartow Mall
2063A Bartow Ave, Bronx, NY 10475
This location card supports referral and scheduling coordination only. Call before medication is shipped to confirm site capability, trained staff, storage, coverage, and the target appointment date. Serves Co-op City, Pelham Bay, Baychester, and nearby Bronx neighborhoods.
Brooklyn
Crown Heights
341 Eastern Pkwy, Brooklyn, NY 11216
This location card supports referral and scheduling coordination only. Call before medication is shipped to confirm site capability, trained staff, storage, coverage, and the target appointment date. Serves Crown Heights, Prospect Heights, and nearby Brooklyn neighborhoods.
Long Island
Hicksville
232 W Old Country Rd, Hicksville, NY 11801
This location card supports referral and scheduling coordination only. Call before medication is shipped to confirm site capability, trained staff, storage, coverage, and the target appointment date. Serves Hicksville, Plainview, Bethpage, and nearby Nassau County communities.
Queens
Jackson Heights
80-10 Northern Blvd, Jackson Heights, NY 11372
This location card supports referral and scheduling coordination only. Call before medication is shipped to confirm site capability, trained staff, storage, coverage, and the target appointment date. Serves Jackson Heights, Elmhurst, Corona, and nearby Queens neighborhoods.
Queens
Jamaica
90-18 Sutphin Blvd, Jamaica, NY 11435
This location card supports referral and scheduling coordination only. Call before medication is shipped to confirm site capability, trained staff, storage, coverage, and the target appointment date. Serves Jamaica, Briarwood, Richmond Hill, and nearby Queens neighborhoods.
Queens
Long Island City
30-07 36th Ave, Astoria, NY 11106
This location card supports referral and scheduling coordination only. Call before medication is shipped to confirm site capability, trained staff, storage, coverage, and the target appointment date. Serves Long Island City, Astoria, Sunnyside, and nearby Queens neighborhoods.
Long Island
Mineola
135 Mineola Blvd, Mineola, NY 11501
This location card supports referral and scheduling coordination only. Call before medication is shipped to confirm site capability, trained staff, storage, coverage, and the target appointment date. Serves Mineola, Garden City, Westbury, and nearby Nassau County communities.
Manhattan
StuyTown
259 1st Ave, New York, NY 10003
This location card supports referral and scheduling coordination only. Call before medication is shipped to confirm site capability, trained staff, storage, coverage, and the target appointment date. Serves StuyTown, the East Village, Gramercy, and nearby Manhattan neighborhoods.
Brooklyn
Williamsburg
308 Graham Ave, Brooklyn, NY 11211
This location card supports referral and scheduling coordination only. Call before medication is shipped to confirm site capability, trained staff, storage, coverage, and the target appointment date. Serves Williamsburg, Greenpoint, Bushwick, and nearby Brooklyn neighborhoods.
Patient questions
Is CABENUVA HIV treatment or PrEP?
CABENUVA is a complete long-acting treatment regimen for eligible people with HIV who are already virologically suppressed. Apretude is long-acting cabotegravir used for HIV PrEP in people without HIV.
Who may qualify for CABENUVA?
The FDA label includes adults and adolescents age 12 or older who weigh at least 35 kg, have HIV-1 RNA below 50 copies/mL on a stable regimen, have no history of treatment failure, and have no known or suspected resistance to cabotegravir or rilpivirine.
Do I have to take oral cabotegravir and rilpivirine first?
Not always. The patient and healthcare provider may choose an oral lead-in to assess tolerability or may proceed directly to injections. The treating HIV clinician makes that decision.
How often is CABENUVA given?
The label provides monthly and every-two-month schedules. Each administration visit includes two gluteal injections. The prescriber selects the schedule and target date.
What happens if I will miss my injection date?
Contact the treating HIV clinician and administration site immediately. The label allows dosing within seven days before or after the target date; longer delays can require oral bridging or re-initiation.
Can Nao Medical replace my HIV clinician?
The ASOC workflow does not replace the clinician responsible for HIV treatment, viral-load monitoring, resistance review, or regimen changes. A separate HIV-treatment evaluation can establish whether broader care is appropriate.
What records are needed for referral?
Bring the current regimen, recent viral load, treatment and resistance history, medication list, allergies, target date, medication-access details, and the referring clinician's contact information.
Will every Nao Medical location have CABENUVA in stock?
No stock promise is made. Medication sourcing, delivery, qualified staff, and appointment timing must be confirmed before an administration visit.
Clinical and public-health sources
These official sources were checked on August 1, 2026. They support the general medical information and do not replace an individual evaluation.
DailyMed, National Library of Medicine
CABENUVA current prescribing information
FDA-labeled eligibility, optional oral lead-in, monthly and every-two-month schedules, missed-dose planning, interactions, injection procedure, and safety warnings.
U.S. Food and Drug Administration
CABENUVA prescribing information
Approved indication, dosing, contraindications, warnings, and administration requirements.
National Institutes of Health
Optimizing antiretroviral therapy with viral suppression
Clinical principles for changing a suppressive HIV regimen and monitoring after a switch.
Publication remains blocked until a named clinical reviewer verifies current guidance, medication labeling, emergency instructions, and Nao Medical's exact care boundary.
Start with the right visit
This location card supports referral and scheduling coordination only. Call before medication is shipped to confirm site capability, trained staff, storage, coverage, and the target appointment date.
Health information notice
General information only. This page is not medical advice and does not replace diagnosis, treatment, or guidance from a licensed clinician.
Content was updated August 1, 2026 from the sources cited on this page. Medical guidance, prescribing information, medication availability, and insurance rules can change. A licensed clinician must confirm current information and determine each patient's eligibility, testing, treatment, administration setting, and follow-up. Call 911 for a medical emergency. Contact Nao Medical with a question or correction.