Availability should be confirmed clinic by clinic
Choose the location that fits your schedule, then call ahead so the care team can review medication access and appointment timing.
Before a visit, confirm the location, responsible prescriber, HIV testing plan, medication supply, trained administrator and next-day tablets. The first appointment may be evaluation rather than administration. If a shipment, authorization or result is pending, ask who tracks it and when you will receive an actual appointment confirmation. The site must also be able to maintain the 26-week follow-up calendar and respond to delayed doses or abnormal HIV results. A product launch, a location listing or FDA approval does not establish that an individual clinic can give the injection today. Continue the agreed prevention method while readiness is checked.
Yeztugo is lenacapavir for prevention of sexually acquired HIV-1 in people who do not have HIV. Treatment starts with injections and tablets, then continues with injections about every six months. It can suit someone who prefers fewer medication visits, provided testing and follow-up remain reliable. Twice-yearly medication does not mean twice-yearly attention to every health concern: a new exposure, symptoms, STI screening or a medication change can require contact sooner.
The approved PrEP indication is for adults and adolescents weighing at least 35 kg who are at risk of acquiring HIV through sex. HIV-negative status must be established. Recent exposure, acute viral symptoms, past PrEP/PEP, pregnancy or breastfeeding and all current medicines belong in the evaluation. HIV testing is required before starting and before each injection. A positive or unknown HIV status prevents use as PrEP.
At initiation, a negative antigen/antibody test is confirmed with HIV RNA testing, even if RNA returns after treatment starts. Before continuation, a negative rapid antigen/antibody test requires confirmation with a more sensitive assay. The clinician determines the complete testing approach and reviews symptoms and any ambiguous results.
Provide every prescription, over-the-counter medicine and supplement. Some strong or moderate CYP3A inducers require additional clinician-directed dosing under the August 2026 label; other starting combinations have no recommended regimen. Your prescriber must review the actual medicines and sequence.
The labeled start includes two subcutaneous injections and oral tablets on the first day, followed by oral tablets the next day. Those tablets are part of required initiation, not an optional tolerability trial. A trained professional administers the injections.
Continuation injections are scheduled every 26 weeks with a two-week allowance on either side. Agree on HIV testing, STI screening and what to do before travel or an access delay.
Bring previous HIV and STI results, your current prevention regimen, last injection date if applicable and insurance information. Ask how the next-day tablets will be obtained and how to contact the team if you cannot take them. Confirm medication receipt and testing arrangements before an administration visit. The label describes abdominal injections and an alternative thigh site; the administrator chooses an appropriate site using the current instructions.
The boxed warning concerns resistance if Yeztugo is used during undetected HIV. Report possible acute HIV symptoms immediately rather than waiting for a routine dose. Injection pain, swelling or nodules can occur; some nodules last a long time. Seek urgent care for severe allergic symptoms or a rapidly worsening injection-site reaction. Lenacapavir can affect other medicines long after the last injection, so tell future prescribers when you received it.
Call before an injection is overdue. An authorized oral bridge may be used for some planned delays, but the tablets are not a patient-designed substitute for injections. Longer gaps without bridging can require repeating initiation after reassessment. After stopping, residual drug may remain for 12 months or longer. Your clinician plans ongoing HIV testing and alternative prevention while levels decline.
Ask separately about tablet coverage, injectable medication coverage, laboratory testing and administration charges. The supply may require authorization and shipment to an administration site. Assistance programs have eligibility rules and do not prove that a particular clinic or insurer participates. Keep a written transition plan while these steps are completed; confirm actual availability before traveling to a listed location.
Ask the selected service for the next available appointment for YEZTUGO PrEP assessment. Confirm whether booking or a walk-in visit is appropriate before traveling. The first visit reviews eligibility, records and the treatment plan. Medication delivery, authorization and an injection appointment may need separate coordination.
Bring previous HIV and STI results, your current prevention regimen, last injection date if applicable and insurance information. Ask how the next-day tablets will be obtained and how to contact the team if you cannot take them. Confirm medication receipt and testing arrangements before an administration visit. The label describes abdominal injections and an alternative thigh site; the administrator chooses an appropriate site using the current instructions.
At initiation, a negative antigen/antibody test is confirmed with HIV RNA testing, even if RNA returns after treatment starts. Before continuation, a negative rapid antigen/antibody test requires confirmation with a more sensitive assay. The clinician determines the complete testing approach and reviews symptoms and any ambiguous results.
Provide every prescription, over-the-counter medicine and supplement. Some strong or moderate CYP3A inducers require additional clinician-directed dosing under the August 2026 label; other starting combinations have no recommended regimen. Your prescriber must review the actual medicines and sequence.
The labeled start includes two subcutaneous injections and oral tablets on the first day, followed by oral tablets the next day. Those tablets are part of required initiation, not an optional tolerability trial. A trained professional administers the injections.
Continuation injections are scheduled every 26 weeks with a two-week allowance on either side. Agree on HIV testing, STI screening and what to do before travel or an access delay.
Ask separately about tablet coverage, injectable medication coverage, laboratory testing and administration charges. The supply may require authorization and shipment to an administration site. Assistance programs have eligibility rules and do not prove that a particular clinic or insurer participates. Keep a written transition plan while these steps are completed; confirm actual availability before traveling to a listed location.
Yeztugo is lenacapavir for prevention of sexually acquired HIV-1 in people who do not have HIV. Treatment starts with injections and tablets, then continues with injections about every six months. It can suit someone who prefers fewer medication visits, provided testing and follow-up remain reliable. Twice-yearly medication does not mean twice-yearly attention to every health concern: a new exposure, symptoms, STI screening or a medication change can require contact sooner.
The approved PrEP indication is for adults and adolescents weighing at least 35 kg who are at risk of acquiring HIV through sex. HIV-negative status must be established. Recent exposure, acute viral symptoms, past PrEP/PEP, pregnancy or breastfeeding and all current medicines belong in the evaluation. HIV testing is required before starting and before each injection. A positive or unknown HIV status prevents use as PrEP.
At initiation, a negative antigen/antibody test is confirmed with HIV RNA testing, even if RNA returns after treatment starts. Before continuation, a negative rapid antigen/antibody test requires confirmation with a more sensitive assay. The clinician determines the complete testing approach and reviews symptoms and any ambiguous results.
Provide every prescription, over-the-counter medicine and supplement. Some strong or moderate CYP3A inducers require additional clinician-directed dosing under the August 2026 label; other starting combinations have no recommended regimen. Your prescriber must review the actual medicines and sequence.
The labeled start includes two subcutaneous injections and oral tablets on the first day, followed by oral tablets the next day. Those tablets are part of required initiation, not an optional tolerability trial. A trained professional administers the injections.
Continuation injections are scheduled every 26 weeks with a two-week allowance on either side. Agree on HIV testing, STI screening and what to do before travel or an access delay.
No. Oral tablets on both initiation days are part of the labeled regimen. Contact your clinician immediately if the second-day tablets are unavailable, missed or vomited; do not improvise replacement doses.
The exact plan must be checked for both formulations, the dispensing route and administration site. Also ask about visits and laboratory charges. Another person’s approval or copay is not a reliable estimate of yours.
A clinician can compare options and make a transition plan based on HIV results, last doses, exposure and interactions. Keep the existing prevention plan until you receive explicit instructions; changing products without coordination can leave a gap.
Book a Yeztugo first visit Call (917) 310-3371
Eligibility, testing and what to bring · Side effects and safety · Starter doses and return visits
Choose the location that fits your schedule, then call ahead so the care team can review medication access and appointment timing.
The right clinic needs to support the medication path, HIV testing workflow, and six-month administration cadence for that patient's plan.
YEZTUGO availability should be confirmed before the patient arrives because coverage, medication routing, and staffing can affect timing.
APRETUDE is an established long-acting PrEP option that may be relevant while patients ask about YEZTUGO access.
Bronx
932 E 174th St, Bronx, NY 10460
A Bronx clinic that can help patients ask about YEZTUGO availability, coverage support, and PrEP follow-up, serving patients in West Farms, Crotona Park East, and nearby Bronx neighborhoods.
View location details Get directionsQueens
37-15 23rd Ave, Astoria, NY 11105
A Queens clinic that can help patients ask about YEZTUGO availability, coverage support, and PrEP follow-up, serving patients in Astoria, Ditmars, East Elmhurst, and nearby Queens neighborhoods.
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Bronx
2063A Bartow Ave, Bronx, NY 10475
A Bronx clinic that can help patients ask about YEZTUGO availability, coverage support, and PrEP follow-up, serving patients in Co-op City, Pelham Bay, Baychester, and nearby Bronx neighborhoods.
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Brooklyn
341 Eastern Pkwy, Brooklyn, NY 11216
A Brooklyn clinic that can help patients ask about YEZTUGO availability, coverage support, and PrEP follow-up, serving patients in Crown Heights, Prospect Heights, and nearby Brooklyn neighborhoods.
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Long Island
232 W Old Country Rd, Hicksville, NY 11801
A Long Island clinic that can help patients ask about YEZTUGO availability, coverage support, and PrEP follow-up, serving patients in Hicksville, Plainview, Bethpage, and nearby Nassau County communities.
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Queens
80-10 Northern Blvd, Jackson Heights, NY 11372
A Queens clinic that can help patients ask about YEZTUGO availability, coverage support, and PrEP follow-up, serving patients in Jackson Heights, Elmhurst, Corona, and nearby Queens neighborhoods.
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Queens
90-18 Sutphin Blvd, Jamaica, NY 11435
A Queens clinic that can help patients ask about YEZTUGO availability, coverage support, and PrEP follow-up, serving patients in Jamaica, Briarwood, Richmond Hill, and nearby Queens neighborhoods.
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Queens
30-07 36th Ave, Astoria, NY 11106
A Queens clinic that can help patients ask about YEZTUGO availability, coverage support, and PrEP follow-up, serving patients in Long Island City, Astoria, Sunnyside, and nearby Queens neighborhoods.
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Long Island
135 Mineola Blvd, Mineola, NY 11501
A Long Island clinic that can help patients ask about YEZTUGO availability, coverage support, and PrEP follow-up, serving patients in Mineola, Garden City, Westbury, and nearby Nassau County communities.
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Manhattan
259 1st Ave, New York, NY 10003
A Manhattan clinic that can help patients ask about YEZTUGO availability, coverage support, and PrEP follow-up, serving patients in StuyTown, East Village, Gramercy, and nearby Manhattan neighborhoods.
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Brooklyn
308 Graham Ave, Brooklyn, NY 11211
A Brooklyn clinic that can help patients ask about YEZTUGO availability, coverage support, and PrEP follow-up, serving patients in Williamsburg, Greenpoint, Bushwick, and nearby Brooklyn neighborhoods.
View location details Get directionsDiscuss which tests are appropriate, how to prepare and how your results will be reviewed.
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