Yeztugo PrEP consultation and ongoing care

Start with an in-person visit for HIV and STI testing, medication ordering, and a primary care plan. Return after the medication reaches the confirmed clinic.

Nao Medical can establish you with a primary care provider or coordinate with your current PCP. The care team confirms the administration clinic and appointment before medication is shipped; same-day stock is not assumed.

HIV testing is required before Yeztugo

Yeztugo must not be started unless HIV-negative status is confirmed. At initiation, a negative antigen/antibody result is confirmed with an HIV-1 RNA test, even when the RNA result returns after treatment starts. HIV testing is also required before each later injection because undiagnosed HIV can lead to drug resistance.

Key clinical guidance

These points affect medication safety, test timing, or follow-up. The linked primary guidance supports each summary.

Testing at the first injection

The FDA label calls for HIV antigen/antibody screening with HIV-1 RNA confirmation at initiation. CDC says an injection does not need to wait for a pending RNA result when the antigen/antibody result is negative and the clinical assessment supports treatment.

Source: FDA Yeztugo prescribing information Source: CDC lenacapavir guidance

Planning after the final dose

Residual lenacapavir can remain for 12 months or longer. Patients with continuing exposure risk need a clinician-directed alternative PrEP plan within 28 weeks of the last injection.

Source: FDA Yeztugo prescribing information

The essentials at a glance

First visit in person

A provider reviews your history, orders required HIV and STI testing, and starts medication and coverage coordination.

Sexual-health follow-up every three months

Ongoing visits support repeat HIV and STI testing, prevention counseling, and primary care needs between injections.

Two injections every six months

After starter dosing, a trained healthcare professional gives two subcutaneous injections every six months.

What to expect from care

The exact plan depends on your history, test results, coverage, and medication choice. These are the usual steps.

First in-person primary care visit

Discuss recent exposures, prior PrEP or PEP, symptoms, medications, allergies, and prevention goals. When appropriate, establish ongoing primary care and complete an annual physical during this visit.
HIV and baseline testing

Complete laboratory antigen/antibody testing and HIV-1 RNA testing at initiation, plus STI and other tests selected for your history. The clinician must document a negative HIV result before administering Yeztugo. If RNA testing is unavailable, CDC recommends repeat laboratory antigen/antibody testing four weeks later.
Prescription, coverage, and clinic delivery

The team orders Yeztugo, starts any required prior authorization, confirms the administration clinic, and coordinates delivery to that clinic. Do not assume the medication is available for a same-day walk-in visit.
Administration visit after delivery

Return after the clinic confirms that the medication has arrived and the required HIV result is documented. The FDA-approved starter schedule includes two injections and oral lenacapavir on day 1, followed by the remaining day-2 tablets as directed.
Next-day telemedicine check

Review injection-site reactions, medication tolerance, adverse effects, and the directions for the remaining starter tablets.
Three-month HIV and STI follow-up

Return every three months for HIV and STI testing, prevention review, and any primary care needs. The six-month injection schedule does not replace these follow-up visits.
Five-month renewal visit

Complete a telemedicine check about one month before the next dose so the team can order the medication and begin the next coverage review.
Six-month continuation visit

Complete required HIV testing and safety review, then receive the next two injections within the prescribed dosing window.

A primary care pathway, not a one-time injection

Yeztugo may be useful for someone who wants PrEP without a daily pill or an injection every two months. The twice-yearly dose is only one part of care. Patients still need repeat HIV and STI testing, medication planning, and timely follow-up.

Nao Medical prefers to establish Yeztugo patients with a primary care provider because the schedule creates regular opportunities to address prevention, annual care, vaccines, and other health needs. If you want to keep your current PCP, the team can coordinate the Yeztugo pathway without requiring you to change primary care providers.

Your clinician must confirm that you do not have HIV, review possible drug interactions, and decide whether the approved indication matches your exposure pattern and health history.

If you are switching from tenofovir-based PrEP, the clinician should assess hepatitis B infection and immunity. Stopping tenofovir can allow hepatitis B to worsen, so chronic hepatitis B may require another treatment and nonimmune patients should be offered vaccination.

Use the first visit for the required testing and a broader primary care review.
Keep the next-day telemedicine check after starter dosing.
Return every three months for HIV and STI follow-up.
Start the next order and coverage review around month five.
Return for the next injection visit around month six.

Medication is delivered to the confirmed clinic

Yeztugo is coordinated through a medical setting. After the first visit, the care team works through prescription, coverage, and delivery requirements before scheduling administration.

Clinic listings show where Nao Medical can start the evaluation and coordination process. They do not promise that every clinic keeps Yeztugo in stock or can administer it during a same-day walk-in visit.

The team confirms the administration site before shipment so the medication reaches the correct clinic and the follow-up visit is scheduled with the right staff and handling process.

Book the first visit before expecting an injection appointment.
Wait for confirmation that coverage and delivery steps are complete.
Confirm the clinic and appointment before medication is shipped.
Call early if the planned injection date may change.

Injection-site reactions and medication safety

Injection-site reactions are common with Yeztugo. Reported reactions include nodules, pain, redness, hardening, and swelling. Some nodules can last for months or longer. Ask what is expected, what comfort measures are reasonable, and when a reaction needs medical review.

Lenacapavir has important drug interactions. Some medicines require supplemental Yeztugo dosing, some combinations are not recommended, and starting Yeztugo while already taking certain enzyme-inducing medicines lacks dosing guidance. Bring a complete list of prescriptions, over-the-counter medicines, and supplements for a pharmacist or prescriber to review.

Tell the clinician if you are pregnant, planning pregnancy, or breastfeeding so the benefits, available safety information, and other PrEP options can be reviewed for your situation.

Lenacapavir can remain in the body for 12 months or longer after the last injection. If Yeztugo is stopped and HIV exposure may continue, the FDA label says another PrEP method should be considered and started within 28 weeks of the last injection.

Call promptly for severe or worsening injection-site symptoms.
Seek urgent help for signs of a serious allergic reaction.
Contact the care team early if the next injection may be late.
Keep scheduled HIV testing even when you feel well.
Plan replacement PrEP before the medication tail creates a prevention gap.

Insurance, prior authorization, and patient support

The consultation, laboratory testing, medication, and administration may process under different benefits. Coverage can depend on your plan, prior authorization, pharmacy-versus-medical benefit rules, and the participating administration site.

Nao Medical can help organize the clinical documentation and benefits review. Gilead Advancing Access also offers benefits investigation and support programs for eligible patients. Program terms and eligibility can change, so confirm current details directly.

Bring your insurance card and pharmacy-benefit information.
Tell the team about any coverage approval you already received.
Ask what the plan covers before medication is ordered.
Confirm the administration location before the injection date.

Start the Yeztugo pathway at a Nao Medical clinic

Use a clinic page for directions and local details. A listed clinic can help start the evaluation and coordination pathway, but Nao Medical confirms the administration site before medication is shipped. Do not assume same-day stock or walk-in administration.