Spravato Treatment in NYC | REMS-Certified Depression Care

Q: How does Spravato work?

Spravato works differently from standard antidepressants. Rather than primarily targeting serotonin, it acts on NMDA receptors and the glutamate system, which may help some patients who have not responded well to standard antidepressant treatments.

Q: What should I do before my first Spravato appointment?

Before your first Spravato appointment, plan a ride home, review medications with your care team, do not eat for at least 2 hours before treatment, avoid liquids for at least 30 minutes before treatment, and expect to stay for at least 2 hours of in-office monitoring after dosing.

Reliable Spravato Treatment Backed by
Certification and Expertise

REMS-Certified Facility

We follow strict safety guidelines to make sure you get safe and high-quality care during your treatment.

Providers Trained by REMS

Our providers are specially trained to give you effective and caring treatment that meets your unique needs.

Proven Success in Treatment

We have a proven track record of helping patients achieve real results with Spravato treatments tailored to their needs.

Understanding Spravato® Treatment in NYC
What Is Spravato® (Esketamine)?

Transformative Therapy:

Spravato® represents a groundbreaking nasal spray sanctioned by the FDA designed to address treatment-resistant depression in adults.

Positive Changes:

Spravato® can provide quick relief from severe depressive symptoms for some eligible patients and may help when standard antidepressant treatment has not provided enough relief.

How It Helps:

Experience a unique approach designed to address depression symptoms effectively, especially when conventional treatments are ineffective.

Insurance Coverage for Spravato in NYC and Long Island

Nao Medical provides Spravato treatment across New York City and Long Island with benefits support built into the intake process. We work with commercial insurance, Medicare, Medicaid, and New York State Medicaid Managed Care plans for eligible patients, and we verify benefits before treatment begins.

Eligible patients are paired with a dedicated care manager who helps keep the process moving, from benefits checks and prior authorization paperwork to scheduling updates and transportation planning for monitored treatment days.

Commercial insurance, Medicare, and Medicaid accepted for Spravato treatment.

New York State Medicaid Managed Care plans accepted, including Healthfirst, Fidelis Care, and United Healthcare Community Plan.

Benefits verification, prior authorization support, and first-visit prep before your initial session.

Molina Healthcare of New York

Healthfirst

MetroPlus

Blue Cross Blue Shield

Aetna

Fidelis of NY Medicaid

Healthfirst Medicaid

United Healthcare

Medicaid

Empire BCBS HealthPlus

Medicare

1199 National Benefit Funds

Fidelis Care New York

United Healthcare Community Plan

Cigna

Emblem Health

GHI - Primary

BCBS Anthem

If you do not see your exact plan listed, call us. Our team can verify Spravato benefits, explain likely prior authorization steps, and walk you through next steps before treatment starts.

Explore Spravato treatment by borough, region, and patient need

Use these supporting pages to compare active clinics, review borough and region access, understand insurance and cost questions, and move into the strongest Spravato path for your location and coverage situation.

Bronx

Bartow gives Bronx patients a local Spravato access point for repeated monitored visits without a cross-borough commute.

Explore Bronx Spravato treatment

Brooklyn

Williamsburg is the lead Brooklyn Spravato location for patients searching in Williamsburg, Greenpoint, Bushwick, and nearby neighborhoods.

Explore Brooklyn Spravato treatment

Queens

Astoria, Long Island City, and Jamaica give Queens patients multiple active access points instead of a single hard-to-reach clinic.

Explore Queens Spravato treatment

Long Island

Mineola and Hicksville support Nassau County demand for monitored Spravato treatment, benefits review, and follow-up coordination.

Explore Long Island Spravato treatment

Manhattan

StuyTown anchors the Manhattan side of the program for patients who want in-city access to supervised Spravato care.

Explore Manhattan Spravato treatment

Insurance and Medicaid

Review how Nao Medical approaches Medicaid, Medicare, Medicare Advantage, and commercial Spravato coverage before treatment starts.

Review Spravato insurance coverage

Cost Guide

Understand what affects out-of-pocket Spravato cost in New York and why benefits verification comes before quoting treatment responsibility.

Review the Spravato cost guide

Locations Near You

Compare all active Spravato clinics across NYC and Long Island if you are searching for the best location near home or work.

View active Spravato locations

FAQs

What is Spravato?

Spravato is the brand name for esketamine nasal spray, an FDA-approved prescription treatment used for certain adults with depression. It is most commonly used for adults with treatment-resistant depression, meaning depression that has not improved enough after trying other antidepressant treatments. Spravato is given in a certified medical setting under supervision as part of a structured treatment plan.

How does Spravato work?

Spravato works differently from standard antidepressants. While many traditional antidepressants mainly affect serotonin, Spravato acts on NMDA receptors in the brain and influences the glutamate system, which plays a role in mood, learning, and neural connectivity. This different mechanism is one reason it may help some patients who have not responded well to standard antidepressants.

Is Spravato FDA-approved?

Yes. Spravato is FDA-approved for eligible adults with treatment-resistant depression and for certain adults with major depressive disorder with acute suicidal thoughts or actions when clinically appropriate. It must be administered in a certified healthcare setting that follows the REMS program and FDA safety requirements.

Is Spravato safe?

Spravato can be safe when it is used appropriately in a certified medical setting under trained supervision. Because it can cause temporary side effects such as sedation, dissociation, and increased blood pressure, patients are monitored after each treatment. Safety protocols are built into the treatment process, including in-office observation and clear guidance about what patients should and should not do after a session.

What are the most common Spravato side effects?

The most common Spravato side effects may include dizziness, dissociation, nausea, sleepiness, feeling disconnected, vertigo, anxiety, and temporary increases in blood pressure. Some people also feel tired or less alert after treatment. These effects are usually monitored in the office and often improve as the treatment session passes. Your provider will review possible side effects with you before starting treatment.

Is Spravato an outpatient treatment?

Yes. Spravato is an outpatient treatment. It is given in-office in a certified medical setting, and patients go home the same day after the required monitoring period. A hospital stay is not usually needed.

How long does each Spravato session take?

Each Spravato session usually takes about two hours or a little longer from start to finish. This includes the time for administration and the required observation period afterward. Patients should plan for the full visit and avoid trying to rush back to normal activities immediately after treatment.

What happens after Spravato treatment?

After Spravato treatment, you stay in the office for monitoring while the clinical team observes your recovery and checks on your safety. Once you are cleared to leave, you go home the same day. You should not drive yourself after treatment, so you will need transportation arranged in advance. Follow-up visits are scheduled based on your treatment plan.

How many sessions are required?

The number of sessions varies by patient, symptoms, and how well treatment is working. Many patients begin with an initial phase that involves more frequent visits, followed by a maintenance phase with less frequent sessions. Your provider will tailor the plan to your progress and your clinical needs.

What is the Spravato dosing schedule?

The Spravato dosing schedule usually starts with an induction phase, often involving twice-weekly treatment for the first few weeks, followed by a maintenance phase where treatment becomes less frequent. The exact schedule depends on your diagnosis, how you respond, and your provider's clinical judgment. Some patients continue weekly treatment for a period, while others may space treatments farther apart over time.

Who qualifies for Spravato?

Spravato may be appropriate for adults with treatment-resistant depression or certain adults with major depressive disorder in specific clinical circumstances. In general, patients being evaluated for treatment-resistant depression have usually tried at least two antidepressants without enough relief. Qualification depends on diagnosis, medication history, symptoms, safety considerations, and overall clinical evaluation.

Does insurance cover Spravato?

Many insurance plans do cover Spravato. Nao Medical works with commercial insurance, Medicare, Medicaid, and New York State Medicaid Managed Care plans, but coverage still depends on your plan benefits, diagnosis, and prior authorization requirements. A benefits check is usually completed before treatment begins so you can understand expected coverage and out-of-pocket cost.

Do you accept Medicaid for Spravato in New York?

Yes. Nao Medical accepts Medicaid for Spravato treatment in New York, including New York State Medicaid Managed Care plans such as Healthfirst, Fidelis Care, and UnitedHealthcare Community Plan, subject to eligibility, benefits verification, and prior authorization requirements.

Does Spravato require prior authorization?

Yes, Spravato often requires prior authorization. Insurance companies commonly ask for documentation showing the diagnosis, previous antidepressant trials, and medical necessity. The approval process can vary by plan, but eligible Nao Medical patients are assigned a care manager who can help gather records, submit paperwork, track status, and keep treatment moving.

Will I have a care manager to help with approval and scheduling?

Yes. Eligible patients are assigned a dedicated care manager who can act as a single point of contact for benefits verification, prior authorization questions, scheduling updates, first-visit preparation, and transportation coordination for treatment days.

Do I need a ride home after Spravato treatment?

Yes. Patients should plan safe transportation home after each Spravato treatment and should not drive or use heavy machinery until the next day after a restful sleep. If transportation is a barrier, our team can help coordinate the logistics before your session.

What should I do before my first Spravato appointment?

Plan a ride home, review your medications with the care team, and expect to stay in the office for at least 2 hours of monitoring after dosing. Patients are generally advised not to eat for at least 2 hours before treatment or drink liquids for at least 30 minutes before treatment. If you use a nasal corticosteroid or nasal decongestant, your clinician may ask you to take it at least 1 hour before Spravato.

What is the difference between Spravato vs ketamine?

Spravato and ketamine are related, but they are not the same. Spravato is the brand name for esketamine nasal spray, which is FDA-approved and administered under a REMS-certified process in a medical office. Ketamine treatment is often used off-label and may be offered in other forms, such as IV infusion, depending on the practice. Patients comparing Spravato vs ketamine usually want to understand differences in approval status, treatment setting, monitoring, and insurance coverage.

How does Spravato compare with TMS?

Spravato and TMS are both advanced treatment options for people with difficult-to-treat depression, but they work very differently. Spravato is a medication-based treatment using esketamine nasal spray in a supervised medical setting. TMS is a non-drug treatment that uses magnetic stimulation to target specific brain regions. They differ in mechanism, treatment schedule, side effects, and patient experience. The best choice depends on the patient's symptoms, treatment history, preferences, and clinical evaluation.

Monday:	8:00 am – 8:00 pm
Tuesday:	8:00 am – 8:00 pm
Wednesday:	8:00 am – 8:00 pm
Thursday:	8:00 am – 8:00 pm
Friday:	8:00 am – 8:00 pm
Saturday:	9:00 am – 4:00 pm
Sunday:	9:00 am – 4:00 pm
Holiday:	9:00 am – 3:00 pm

Monday:	10:00 am – 6:00 pm
Tuesday:	10:00 am – 6:00 pm
Wednesday:	10:00 am – 6:00 pm
Thursday:	10:00 am – 6:00 pm
Friday:	10:00 am – 6:00 pm
Saturday:	10:00 am – 6:00 pm
Sunday:	9:00 am – 4:00 pm
Holiday:	9:00 am – 3:00 pm

Monday:	8:00 am – 7:00 pm
Tuesday:	8:00 am – 7:00 pm
Wednesday:	8:00 am – 7:00 pm
Thursday:	8:00 am – 7:00 pm
Friday:	8:00 am – 5:30 pm
Saturday:	9:00 am – 4:00 pm
Sunday:	9:00 am – 4:00 pm
Holiday:	9:00 am – 3:00 pm

Monday:	9:00 am – 7:00 pm
Tuesday:	9:00 am – 7:00 pm
Wednesday:	9:00 am – 7:00 pm
Thursday:	9:00 am – 7:00 pm
Friday:	9:00 am – 7:00 pm
Saturday:	9:00 am – 4:30 pm
Sunday:	9:00 am – 4:30 pm
Holiday:	9:00 am – 3:00 pm

Monday:	8:00 am – 8:00 pm
Tuesday:	8:00 am – 8:00 pm
Wednesday:	8:00 am – 8:00 pm
Thursday:	8:00 am – 8:00 pm
Friday:	8:00 am – 8:00 pm
Saturday:	9:00 am – 4:00 pm
Sunday:	9:00 am – 4:00 pm
Holiday:	9:00 am – 3:00 pm

Don't Let Depression Keep You in the Dark.
Spravato® Treatment in New York City and Long Island