Spravato vs Ketamine Infusions: Which One Is Better for Treating Depression?

Comparing Spravato and Ketamine Infusions for Treatment-Resistant Depression

If you’re struggling with depression and have tried numerous treatments to no avail, you might be interested in the latest therapies available: Spravato and ketamine infusions. Both of these treatments have shown promise in treating treatment-resistant depression. But which one is better for you? Let’s compare them.


Spravato, also known as esketamine, is a nasal spray recently approved by the FDA for treating depression in adults who have not responded to other treatments. The active ingredient in Spravato is a type of ketamine. It is administered under medical supervision, typically twice a week for the first four weeks, then once a week or once every two weeks, depending on how the patient responds.

Ketamine Infusions

Ketamine infusions, on the other hand, are administered intravenously under medical supervision. Ketamine is a type of anesthetic that has been used for decades in surgical and emergency settings. However, in recent years, it has been found to have a rapid and robust antidepressant effect, especially in patients with treatment-resistant depression. Ketamine infusions typically involve a series of treatments over a few weeks, with the frequency tapering off as the patient responds.


Both Spravato and ketamine infusions have shown to be effective in treating treatment-resistant depression, with rapid and robust antidepressant effects. However, research has shown that ketamine infusions may be more effective in some cases, especially in patients with severe and treatment-resistant depression. In contrast, Spravato has been shown to be more effective than placebo, but its effectiveness compared to ketamine infusions is still being studied.

Side Effects

Both treatments may have side effects, although they are generally well-tolerated. Common side effects of Spravato include dizziness, sedation, and dissociation, which is a sense of detachment from one’s surroundings or oneself. Ketamine infusions may cause similar side effects, as well as nausea and vomiting. However, the risk of side effects can be minimized with proper medical supervision.


The cost of both treatments can vary widely, depending on factors such as the dosage, frequency, and duration of treatment. Spravato is typically more expensive than ketamine infusions, especially considering the fact that it requires regular visits to a healthcare provider’s office. Ketamine infusions may be less expensive in the long run, as the frequency of treatment can be tapered off over time.

At Nao Medical, we offer a comprehensive range of mental health services, including Spravato and ketamine infusions. Our caring and knowledgeable staff will work with you to find the best treatment option for your needs, taking into account your medical history, symptoms, and preferences. Book an appointment with us today and take the first step toward feeling better.


Q: Can Spravato and ketamine infusions be used together?

A: It is not recommended to use Spravato and ketamine infusions together, as there is not enough research on their combined use. It is important to discuss all of your treatment options with your healthcare provider to determine the best course of action for your individual needs.

Q: Are there any long-term side effects of Spravato or ketamine infusions?

A: The long-term side effects of both treatments are not yet known, as they are relatively new treatments. However, both treatments are administered under medical supervision and the risk of side effects can be minimized with proper monitoring.

Q: How soon can I expect to see results from Spravato or ketamine infusions?

A: Both treatments have shown rapid and robust antidepressant effects, with some patients reporting improvement within hours of the treatment.

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Disclaimer: The information presented in this article is intended for general informational purposes only and should not be considered, construed or interpreted as legal or professional advice, guidance or opinion.

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