What treatment-resistant depression means

Treatment-resistant depression generally refers to depression that has not improved enough after adequate treatment attempts. A Spravato evaluation reviews prior medications, symptom history, safety needs, medical risks, and whether monitored esketamine treatment is appropriate.

What Spravato treatment includes

Spravato is administered as an intranasal medication under supervision in a certified healthcare setting. Patients are monitored after dosing and need transportation home. Follow-up reviews response, tolerability, scheduling, and whether treatment should continue.

How Nao Medical supports the process

  • Psychiatric evaluation for eligible adults.
  • Insurance and Medicaid benefits review.
  • Prior authorization coordination when required.
  • In-office monitoring after each treatment.
  • Coordination with outside psychiatrists when appropriate.

Clinical references reviewed: SPRAVATO REMS and the FDA prescribing information. Last reviewed May 2026. This information does not replace a clinical evaluation.

Active Nao Medical Spravato locations

Queens

Astoria

37-15 23rd Ave, Astoria, NY 11105

A western Queens option for patients who want easier access than crossing into Manhattan for every monitored treatment day.

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Bronx

Bartow

2063A Bartow Ave, Bronx, NY 10475

A Bronx access point for patients who want local Spravato care without leaving the borough.

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Long Island

Hicksville

232 W Old Country Rd, Hicksville, NY 11801

A central Nassau option for patients who need consistent follow-up, prior auth support, and a shorter commute.

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Queens

Jamaica

90-18 Sutphin Blvd, Jamaica, NY 11435

A southeast Queens location that helps patients stay on schedule for repeated monitored sessions.

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Queens

Long Island City

30-07 36th Ave, Astoria, NY 11106

A western Queens access point for patients balancing treatment days with work, home, or Manhattan commutes.

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Long Island

Mineola

135 Mineola Blvd, Mineola, NY 11501

A Long Island access point for patients who want strong benefits support and reliable treatment coordination.

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Manhattan

StuyTown

259 1st Ave, New York, NY 10003

A Manhattan Spravato access point for East Village, Gramercy, Kips Bay, and nearby neighborhoods.

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Brooklyn

Williamsburg

308 Graham Ave, Brooklyn, NY 11211

The lead Brooklyn Spravato location for patients who want local access and ongoing psychiatric support.

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Insurance Plans We Accept

Accepted plans can vary by eligibility and authorization rules. This list reflects the insurance access Nao Medical can review for eligible Spravato patients, including Medicaid, Medicare, Medicare Advantage, and commercial coverage options.

  • Molina Healthcare of New York
  • Healthfirst
  • MetroPlus
  • Blue Cross Blue Shield
  • Aetna
  • Fidelis of NY Medicaid
  • Healthfirst Medicaid
  • United Healthcare
  • Medicaid
  • Empire BCBS HealthPlus
  • Medicare
  • 1199 National Benefit Funds
  • Fidelis Care New York
  • United Healthcare Community Plan
  • Cigna
  • Emblem Health
  • GHI - Primary
  • BCBS Anthem

Frequently asked questions

Does Spravato cure treatment-resistant depression?

No treatment can be promised as a cure. Spravato may help eligible adults, but response varies and ongoing clinical follow-up is important.

Can Spravato be used without an oral antidepressant?

For treatment-resistant depression, Spravato may be used as monotherapy or with an oral antidepressant based on current prescribing information and clinical review.

How soon will I know if Spravato is helping?

Response timing varies. For treatment-resistant depression, benefit is commonly reviewed after the initial treatment period and during follow-up visits.

Can I continue therapy during Spravato treatment?

Yes. Therapy and other mental health support may remain part of the care plan when clinically appropriate.